Research Articles
Analyzing the 2024 WHO Priority Pathogen Lists: A Strategic Guide for AMR Research and Pandemic Preparedness
This analysis provides researchers, scientists, and drug development professionals with a comprehensive examination of the World Health Organization's updated 2024 pathogen lists.
Optimizing Novel Anti-Infective Agents: A PK/PD and Pharmacometric Framework for Modern Drug Development
This article provides a comprehensive analysis of the pharmacokinetic (PK) and pharmacodynamic (PD) properties underpinning the development of novel anti-infective agents.
Antimicrobial Peptides from Lactiplantibacillus plantarum: Discovery, Mechanisms, and Biotechnological Applications in Drug Development
This article provides a comprehensive resource for researchers and drug development professionals on the diverse arsenal of antimicrobial peptides (AMPs) produced by Lactiplantibacillus plantarum.
Bioactive Mycoconstituents of Pleurotus opuntiae: A Novel Frontier in Combating Antimicrobial Resistance
This article comprehensively explores the antimicrobial potential of Pleurotus opuntiae, an underexplored medicinal mushroom.
Beyond Antibiotics: A Comprehensive Review of Novel Therapies for Drug-Resistant Bacterial Infections
The escalating crisis of antimicrobial resistance (AMR) threatens to reverse a century of medical progress.
Beyond Traditional Antibiotics: Next-Generation Strategies to Combat Multidrug-Resistant Pathogens
The escalating crisis of antimicrobial resistance (AMR) demands a paradigm shift in antibacterial development.
Confronting the Crisis: Decoding Antimicrobial Resistance Mechanisms in Gram-Negative Bacteria
This article provides a comprehensive analysis of the sophisticated mechanisms underpinning antimicrobial resistance (AMR) in Gram-negative bacteria, a critical global health threat.
Beyond Traditional Antibiotics: A Comparative Analysis of Antimicrobial Peptides as Next-Generation Therapeutics
With antimicrobial resistance (AMR) directly causing millions of deaths annually and projected to worsen, the development of novel therapeutic strategies is a critical global health priority. This article provides a comprehensive comparative analysis for researchers and drug development professionals, contrasting traditional antibiotics with emerging antimicrobial peptides (AMPs). We explore the foundational mechanisms of both drug classes, detail the methodological advances in AMP design and production, troubleshoot key challenges in clinical translation, and validate their potential through a direct comparison of efficacy, resistance development, and clinical applicability. The synthesis of these perspectives underscores the transformative role AMPs could play in combating multidrug-resistant infections, both as standalone agents and in synergistic combination therapies.
Nature's Flu Fighter: How a Plant Compound Stops Influenza Before It Starts
Discover how deoxyshikonin, a natural plant compound, inhibits influenza A virus infection at early stages through groundbreaking research.
Scorpion Venom to the Rescue: How an Ancient Creature's Secret Could Solve Our Modern Antibiotic Crisis
Discover how scorpion-derived peptide GK8 fights antibiotic-resistant Pseudomonas aeruginosa through multiple mechanisms of action.