Research Articles
Integron Integrases: Functional Mechanisms, Antibiotic Resistance, and Novel Therapeutic Strategies
This article provides a comprehensive resource for researchers, scientists, and drug development professionals engaged in the functional characterization of integron integrases (IntIs).
Fitness Cost of Antibiotic Resistance Genes: Mechanisms, Measurement, and Therapeutic Implications
This review synthesizes current research on the fitness costs associated with acquired antibiotic resistance genes (ARGs) in bacterial pathogens.
Fitness Cost Analysis: Weighing the Trade-offs of Horizontal Gene Transfer in Antibiotic Resistance Evolution
This article provides a comprehensive analysis of the fitness costs associated with different mechanisms of antibiotic resistance gene (ARG) acquisition in bacterial populations.
Beyond Transfer: A Comprehensive Evaluation of Mathematical Models for Horizontal Gene Transfer (HGT) Prediction in Genomic Analysis
This article provides a critical and up-to-date evaluation of mathematical and computational models used for predicting Horizontal Gene Transfer (HGT), a key driver of microbial evolution and antibiotic resistance.
Unmasking the Safety Profile: A Comprehensive EudraVigilance Database Analysis of Anti-Infective Agents
This article provides a targeted analysis for researchers, scientists, and drug development professionals on leveraging the EudraVigilance database to evaluate anti-infective safety.
The Ethidium Bromide-Agar Cartwheel Method: A Comprehensive Guide for Efflux Pump Activity Detection in Drug-Resistant Pathogens
This article provides a detailed, step-by-step guide to the Ethidium Bromide-Agar Cartwheel (EB-AC) method, a classic and accessible qualitative assay for detecting active efflux in bacterial pathogens.
Targeting Horizontal Gene Transfer: A Comparative Analysis of CRISPR-Based, Phage-Derived, and Small-Molecule Inhibition Strategies in Combating Antibiotic Resistance
This article provides a comprehensive comparison of modern strategies to inhibit Horizontal Gene Transfer (HGT), a primary driver of multi-drug resistant bacterial infections.
Biochar vs. SCFAs: Comparative Strategies to Curb Antibiotic Resistance Gene Spread in Biomedical Applications
This article provides a comprehensive analysis of two promising strategies for mitigating the environmental and clinical spread of Antibiotic Resistance Genes (ARGs): biochar and Short-Chain Fatty Acids (SCFAs).
EUCAST Broth Microdilution: The Definitive Guide for Antimicrobial Susceptibility Testing in Research & Development
This comprehensive guide details the European Committee on Antimicrobial Susceptibility Testing (EUCAST) broth microdilution (BMD) method, the gold standard for in vitro antimicrobial susceptibility testing (AST).
Defeating the Unbeatable: ESKAPE Pathogens, Biofilm-Mediated Treatment Failures, and the Race for Novel Therapeutics
This comprehensive review addresses the critical challenge of antimicrobial resistance posed by ESKAPE pathogens (*Enterococcus faecium*, *Staphylococcus aureus*, *Klebsiella pneumoniae*, *Acinetobacter baumannii*, *Pseudomonas aeruginosa*, and *Enterobacter* species) through the lens...