Research Articles
Scaling Up Bacteriocin Production: Bioprocess Optimization and Therapeutic Applications for Drug Development
This article provides a comprehensive analysis of the scientific and industrial landscape for the large-scale production of bacteriocins from probiotic bacteria.
Pharmacometric Modeling and Simulation: Revolutionizing Anti-Infective Drug Development and Precision Dosing
This article provides a comprehensive overview of the critical role pharmacometric modeling and simulation (M&S) plays in the development and optimization of anti-infective therapies.
Broth Microdilution Method: A Comprehensive Guide to Antimicrobial Susceptibility Testing
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to the broth microdilution method, the predominant technique for antimicrobial susceptibility testing in the U.S.
HPTLC Fingerprinting for Standardization of Bioactive Antimicrobial Compounds: A Comprehensive Guide for Pharmaceutical Analysis
This article provides a comprehensive examination of High-Performance Thin-Layer Chromatography (HPTLC) as a robust analytical tool for standardizing bioactive antimicrobial compounds from natural products.
INT Colorimetric Assay for MIC Determination: A Comprehensive Guide from Principle to Precision
This article provides a thorough exploration of the p-iodonitrophenyltetrazolium violet (INT) colorimetric assay for determining the Minimum Inhibitory Concentration (MIC) of antimicrobial agents.
Therapeutic Drug Monitoring of Narrow Therapeutic Index Antibiotics: Protocols for Precision Dosing in Critical Care and Drug Development
This article provides a comprehensive resource for researchers, scientists, and drug development professionals on therapeutic drug monitoring (TDM) protocols for narrow therapeutic index (NTI) antibiotics.
Population Pharmacokinetic Modeling for Anti-infective Dose Optimization: A Comprehensive Guide for Researchers
This article provides a comprehensive overview of population pharmacokinetic (PopPK) modeling and its critical application in optimizing anti-infective therapy, particularly in challenging patient populations like the critically ill.
Agar Well Diffusion Method: A Complete Guide to Antimicrobial Activity Screening
This article provides a comprehensive guide to the agar well diffusion method, a cornerstone technique for in vitro antimicrobial activity screening.
Horizontal Gene Transfer: Unveiling the Mechanisms Driving the Spread of Antibiotic Resistance
This article provides a comprehensive analysis of the mechanisms, dynamics, and control of transferable antibiotic resistance genes (ARGs), a primary driver of the global antimicrobial resistance crisis.
Optimizing Antibacterial Production with Response Surface Methodology: A Comprehensive Guide for Biomedical Research
This article provides a comprehensive guide on applying Response Surface Methodology (RSM) to optimize the production of antibacterials, such as bacteriocins and novel metabolites, from microbial sources.