Research Articles
Synthetic vs. Natural Antimicrobials: A 2025 Efficacy Comparison for Drug Development
This article provides a comprehensive analysis for researchers and drug development professionals on the efficacy of synthetic versus natural antimicrobial compounds.
Time-Kill Kinetics Assay: A Comprehensive Protocol Guide for Antimicrobial Evaluation
This article provides a comprehensive guide for researchers and drug development professionals on the time-kill kinetics assay, a crucial in vitro method for characterizing the bactericidal or bacteriostatic activity of...
Beyond Traditional Antibiotics: A Comparative Analysis of Antimicrobial Peptides as Next-Generation Therapeutics
With antimicrobial resistance (AMR) directly causing millions of deaths annually and projected to worsen, the development of novel therapeutic strategies is a critical global health priority.
Comparative Safety Profiles of Novel Anti-Infective Agents: A 2025 Analysis for Drug Development Professionals
This article provides a comprehensive analysis of the safety and tolerability profiles of novel anti-infective agents currently in development and recently approved.
Plant-Derived vs. Microbial-Derived Antimicrobials: A Comparative Analysis for Overcoming Drug Resistance
The escalating global crisis of antimicrobial resistance (AMR) necessitates the urgent discovery of novel anti-infective agents.
Head-to-Head Comparison of Anti-Infective Dosing Regimens in Specific Populations: A Comprehensive Framework for Clinical Researchers
This article provides a systematic framework for designing and evaluating head-to-head comparisons of anti-infective dosing regimens in specific patient populations.
Validating Pharmacometric Models for Dose Prediction: A Framework for Accuracy, Credibility, and Clinical Application
This article provides a comprehensive guide for researchers and drug development professionals on the validation of pharmacometric models for accurate dose prediction.
Combination Therapy vs Monotherapy: A Comprehensive Analysis of Clinical Outcomes, Mechanisms, and Future Directions
This article provides a comprehensive analysis of the clinical outcomes of combination therapy versus monotherapy across diverse medical fields including oncology, infectious diseases, and rheumatology.
Validation of Large Language Models for Antibiotic Prescribing: Accuracy, Challenges, and Future Directions
This article comprehensively examines the validation of large language models (LLMs) for antibiotic prescribing accuracy, a critical intersection of artificial intelligence and clinical decision-making.
Bridging the Gap: A Comprehensive Guide to In Vitro-In Vivo Correlation of Anti-Infective Efficacy
Establishing a reliable correlation between in vitro and in vivo efficacy (IVIVC) is a critical yet challenging endeavor in anti-infective drug development.