Research Articles
Breaking the Chain: Innovative Strategies to Disrupt Biofilm-Mediated Antibiotic Resistance Gene Transfer
This article provides a comprehensive review of current strategies aimed at preventing horizontal gene transfer (HGT) within microbial biofilms, a critical nexus for the proliferation of antimicrobial resistance (AMR).
Mastering Population PK Analysis: A Comprehensive Guide to Pmetrics Software for Drug Development
This definitive guide explores Pmetrics, a robust nonparametric and parametric population pharmacokinetic (PK) modeling package for R.
Boosting Drug Success Rates: A 2024 Guide to PK/PD Target Attainment Analysis and Optimization
This comprehensive guide explores advanced strategies for improving Pharmacokinetic/Pharmacodynamic (PK/PD) target attainment rates in modern drug development.
Extending Therapeutic Lifespan: PEGylation Strategies to Overcome Antimicrobial Peptide (AMP) Half-Life Limitations
This article explores the critical application of PEGylation to enhance the circulating half-life of antimicrobial peptides (AMPs), a promising yet pharmaceutically challenging class of therapeutics.
PBPK vs. PopPK Modeling in Anti-Infective Development: Choosing the Right Pharmacokinetic Tool for Success
This article provides a comprehensive guide for drug development scientists on selecting and applying physiologically-based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) modeling in anti-infective development.
Predicting DDIs in Anti-Infective Therapy: A Comprehensive Guide to PBPK Modeling Strategies
Physiologically-Based Pharmacokinetic (PBPK) modeling has emerged as a critical tool for predicting and understanding Drug-Drug Interactions (DDIs) in anti-infective therapy.
Accelerating Anti-Infective Drug Development: A Comprehensive Guide to PBPK Modeling for Candidate Selection
This article provides a detailed guide for researchers and drug development professionals on applying Physiologically-Based Pharmacokinetic (PBPK) modeling to optimize anti-infective candidate selection.
Breaking the Wall: Strategies to Overcome GC Barriers in Pathogen Genetic Manipulation
This article provides a comprehensive analysis for researchers and drug development professionals on the challenges and solutions for genetic manipulation in high-GC content pathogens.
Advanced Strategies for Detecting Low-Frequency Antibiotic Resistance Gene Transfer: Methods and Validation
This article provides a comprehensive guide for researchers and drug development professionals on optimizing the detection of low-frequency antibiotic resistance gene (ARG) transfer.
Integrating Human, Animal, and Environmental Health: A One Health Framework for Combating Antimicrobial Resistance
This article provides a comprehensive analysis of the One Health approach as a critical framework for preventing and mitigating antimicrobial resistance (AMR).