Research Articles
Optimizing Anti-infective Dosing in Critically Ill Patients: Integrating PK/PD, TDM, and Novel Technologies for Improved Outcomes
Critically ill patients present profound pathophysiological changes that significantly alter antimicrobial pharmacokinetics, leading to a high risk of therapeutic failure or toxicity.
Overcoming the Wall: Innovative Strategies to Defeat Gram-Negative Bacterial Resistance by Mastering Membrane Permeability
This article addresses the critical challenge of the Gram-negative outer membrane, a formidable barrier that severely limits antibiotic efficacy and contributes to the antimicrobial resistance (AMR) crisis.
Optimizing Temperature and pH for Maximum Antibacterial Production: A Research and Development Guide
This article provides a comprehensive guide for researchers and drug development professionals on the critical role of temperature and pH optimization in maximizing the production of antibacterial agents.
Overcoming Efflux Pump-Mediated Antibiotic Resistance: From Molecular Mechanisms to Clinical EPI Strategies
Efflux pumps are transport proteins that actively expel antibiotics from bacterial cells, conferring multidrug resistance and contributing to treatment failures.
Scaling Up Bacteriocin Production: Bioprocess Optimization and Therapeutic Applications for Drug Development
This article provides a comprehensive analysis of the scientific and industrial landscape for the large-scale production of bacteriocins from probiotic bacteria.
Pharmacometric Modeling and Simulation: Revolutionizing Anti-Infective Drug Development and Precision Dosing
This article provides a comprehensive overview of the critical role pharmacometric modeling and simulation (M&S) plays in the development and optimization of anti-infective therapies.
Broth Microdilution Method: A Comprehensive Guide to Antimicrobial Susceptibility Testing
This article provides researchers, scientists, and drug development professionals with a comprehensive guide to the broth microdilution method, the predominant technique for antimicrobial susceptibility testing in the U.S.
HPTLC Fingerprinting for Standardization of Bioactive Antimicrobial Compounds: A Comprehensive Guide for Pharmaceutical Analysis
This article provides a comprehensive examination of High-Performance Thin-Layer Chromatography (HPTLC) as a robust analytical tool for standardizing bioactive antimicrobial compounds from natural products.
INT Colorimetric Assay for MIC Determination: A Comprehensive Guide from Principle to Precision
This article provides a thorough exploration of the p-iodonitrophenyltetrazolium violet (INT) colorimetric assay for determining the Minimum Inhibitory Concentration (MIC) of antimicrobial agents.
Therapeutic Drug Monitoring of Narrow Therapeutic Index Antibiotics: Protocols for Precision Dosing in Critical Care and Drug Development
This article provides a comprehensive resource for researchers, scientists, and drug development professionals on therapeutic drug monitoring (TDM) protocols for narrow therapeutic index (NTI) antibiotics.